![This is blank.](https://digitalhistology.org/wp-content/themes/histology-unified/imgs/trans.png)
Endochondral ossification
The end of the zone of maturation-hypertrophy-calcification is located at the top of this image. The zone of degeneration is in the middle, and the zone of ossification is at the bottom of the image. 400x
![Zones of M-H-C > <p>In the zone of maturation-hypertrophy-calcification, linearly arranged chondrocytes increase in size and secrete alkaline phosphatase, thus allowing the matrix to calcify.</p>](https://digitalhistology.org/wp-content/uploads/2018/02/T.J.C.B.F.E.09.P01.png)
Zones of M-H-C >
In the zone of maturation-hypertrophy-calcification, linearly arranged chondrocytes increase in size and secrete alkaline phosphatase, thus allowing the matrix to calcify.
![Zone of degeneration > <p>In the zone of degeneration (yellow arrow), chondrocytes have died, leaving behind the calcified cartilage spicules (red arrows) that separated the isogenous groups.</p>](https://digitalhistology.org/wp-content/uploads/2018/02/T.J.C.B.F.E.09.P02.png)
Zone of degeneration >
In the zone of degeneration (yellow arrow), chondrocytes have died, leaving behind the calcified cartilage spicules (red arrows) that separated the isogenous groups.
![Zone of ossification > <p>In the zone of ossification (yellow arrow), osteoblasts deposit woven bone (stained red; black arrows), on the calcified cartilage framework. Because this bone is replacing cartilage, this type of bone formation called endochondral bone formation.</p>](https://digitalhistology.org/wp-content/uploads/2018/05/T.J.C.B.F.E.09.P03.png)
Zone of ossification >
In the zone of ossification (yellow arrow), osteoblasts deposit woven bone (stained red; black arrows), on the calcified cartilage framework. Because this bone is replacing cartilage, this type of bone formation called endochondral bone formation.