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Stratum spinosum
Stratum spinosum contains 3-10 layers of polygonal keratinocytes with euchromatic nuclei. These cells possess prominent tonofibrils, bundles of intermediate filaments (tonofilaments) composed of keratin protein. Adjacent keratinocytes are attached by numerous desmosomes, creating the spiny appearance around their periphery. 200x, 1,500x

Stratum spinosum cells
Stratum spinosum contains 3-10 layers of polygonal keratinocytes with euchromatic nuclei. These cells possess prominent tonofibrils, bundles of intermediate filaments (tonofilaments) composed of keratin protein. Adjacent keratinocytes are attached by numerous desmosomes, creating the spiny appearance around their periphery. 200x, 1,500x

- Tonofibrils
Stratum spinosum contains 3-10 layers of polygonal keratinocytes with euchromatic nuclei. These cells possess prominent tonofibrils, bundles of intermediate filaments (tonofilaments) composed of keratin protein. Adjacent keratinocytes are attached by numerous desmosomes, creating the spiny appearance around their periphery. 200x, 1,500x