Lymph node: secondary nodule

This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x

This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x

This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x

This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x

This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x

This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x

This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x