Germinal center

The germinal center contains immunoblasts, cells with large, euchromatic nuclei and abundant cytoplasm.  These cells divide, eventually giving rise to small, B lymphocytes that accumulate at the periphery; mitotic figures reflect this activity.  Antigen-presenting cells and macrophages with engulfed, phagocytosed particles are also present in the germinal center.

The germinal center contains immunoblasts, cells with large, euchromatic nuclei and abundant cytoplasm.  These cells divide, eventually giving rise to small, B lymphocytes that accumulate at the periphery; mitotic figures reflect this activity.  Antigen-presenting cells and macrophages with engulfed, phagocytosed particles are also present in the germinal center.

The germinal center contains immunoblasts, cells with large, euchromatic nuclei and abundant cytoplasm.  These cells divide, eventually giving rise to small, B lymphocytes that accumulate at the periphery; mitotic figures reflect this activity.  Antigen-presenting cells and macrophages with engulfed, phagocytosed particles are also present in the germinal center.

Macrophages (tingible body macrophages), with phagosomes in their cytoplasm, indicate the phagocytic activity occurring in the germinal center.  The term “tingible” refers to the fact that the phagocytosed material is stainable.

The germinal center contains immunoblasts, cells with large, euchromatic nuclei and abundant cytoplasm.  These cells divide, eventually giving rise to small, B lymphocytes that accumulate at the periphery; mitotic figures reflect this activity.  Antigen-presenting cells and macrophages with engulfed, phagocytosed particles are also present in the germinal center.

The stroma of the entire lymph node is reticular connective tissue, an open meshwork of delicate reticular fibers on which are suspended the various cells functioning in the node and in this nodule.  Reticular cells that produce this meshwork have nuclei that resemble those of active fibroblasts.