Spleen: white pulp
The marginal zone is a region located at the interface of the PALS with the red pulp. The marginal zone contains numerous thin walled blood sinuses, which are supplied by radial branches from the central arteriole. The surrounding reticular tissue contains numerous lymphocytes and macrophages. The marginal zone is an important transit area for both immune cells and antigens and for the initiation of an immune response. 400x
Germinal center
The marginal zone is a region located at the interface of the PALS with the red pulp. The marginal zone contains numerous thin walled blood sinuses, which are supplied by radial branches from the central arteriole. The surrounding reticular tissue contains numerous lymphocytes and macrophages. The marginal zone is an important transit area for both immune cells and antigens and for the initiation of an immune response. 400x
Periarterial lymphoid sheath (PALS)
The marginal zone is a region located at the interface of the PALS with the red pulp. The marginal zone contains numerous thin walled blood sinuses, which are supplied by radial branches from the central arteriole. The surrounding reticular tissue contains numerous lymphocytes and macrophages. The marginal zone is an important transit area for both immune cells and antigens and for the initiation of an immune response. 400x
Red Pulp
The marginal zone is a region located at the interface of the PALS with the red pulp. The marginal zone contains numerous thin walled blood sinuses, which are supplied by radial branches from the central arteriole. The surrounding reticular tissue contains numerous lymphocytes and macrophages. The marginal zone is an important transit area for both immune cells and antigens and for the initiation of an immune response. 400x
Marginal zone
The marginal zone is a region located at the interface of the PALS with the red pulp. The marginal zone contains numerous thin walled blood sinuses, which are supplied by radial branches from the central arteriole. The surrounding reticular tissue contains numerous lymphocytes and macrophages. The marginal zone is an important transit area for both immune cells and antigens and for the initiation of an immune response. 400x
Marginal sinuses
The marginal zone is a region located at the interface of the PALS with the red pulp. The marginal zone contains numerous thin walled blood sinuses, which are supplied by radial branches from the central arteriole. The surrounding reticular tissue contains numerous lymphocytes and macrophages. The marginal zone is an important transit area for both immune cells and antigens and for the initiation of an immune response. 400x
Penicillar arteriole >
The central arteriole passes out of the PALS and into the red pulp as the penicillar arteriole which branches into capillaries that either supply the splenic cords or are continuous with the splenic sinuses.