![This is blank.](https://digitalhistology.org/wp-content/themes/histology-unified/imgs/trans.png)
Macrophage
Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)
![Monocyte in blood <p>Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)</p>](https://digitalhistology.org/wp-content/uploads/2018/05/T.CT_.CTP_.Cells-13-1-ping.png)
Monocyte in blood
Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)
![Macrophages in tissue <p>Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)</p>](https://digitalhistology.org/wp-content/uploads/2018/05/T.CT_.CTP_.Cells-13-2-ping.png)
Macrophages in tissue
Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)
![Nuclear indentation <p>Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)</p>](https://digitalhistology.org/wp-content/uploads/2018/05/T.CT_.CTP_.Cells-13-3-ping.png)
Nuclear indentation
Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)
![Cytoplasm <p>Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)</p>](https://digitalhistology.org/wp-content/uploads/2018/05/T.CT_.CTP_.Cells-13-4-ping.png)
Cytoplasm
Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)
![Lysosomes <p>Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)</p>](https://digitalhistology.org/wp-content/uploads/2018/05/T.CT_.CTP_.Cells-13-5-ping.png)
Lysosomes
Macrophages are the major phagocytic cell in connective tissue. They are derived from blood-borne monocytes (upper left) that migrate into the tissue (two lower left panels). The ultrastructure of a macrophage is shown on the right. Macrophage nuclei are oval-shaped and frequently indented, reflecting the cell’s origin from a monocyte. The pink cytoplasm, when visible, contains numerous lysosomes and phagocytosed material. 1000x (LM), 8000x (EM)
![Membrane ruffles > <p>Macrophages are highly motile, phagocytic cells and possess a heavily folded and ruffled plasma membrane.</p>](https://digitalhistology.org/wp-content/uploads/2018/05/T.CT_.CTP_.Cells-13-6-ping.png)
Membrane ruffles >
Macrophages are highly motile, phagocytic cells and possess a heavily folded and ruffled plasma membrane.