Resorption canal progression

This series of images shows stages in the life span of a bone remodeling unit (BRU), a two-stage process whereby cortical bone is remodeled from within.  The first stage of a BRU begins with osteoclastic erosion of bone in a “resorption canal” that advances lengthwise within the bone, forming a tunnel.  In the second stage, osteoblasts deposit bone, beginning at the origin of the resorption canal, which creates the “closing end” of the BRU. The continued centripal deposition of lamellae creates a new osteon.

This series of images shows stages in the life span of a bone remodeling unit (BRU), a two-stage process whereby cortical bone is remodeled from within.  The first stage of a BRU begins with osteoclastic erosion of bone in a “resorption canal” that advances lengthwise within the bone, forming a tunnel.  In the second stage, osteoblasts deposit bone, beginning at the origin of the resorption canal, which creates the “closing end” of the BRU. The continued centripal deposition of lamellae creates a new osteon.

This series of images shows stages in the life span of a bone remodeling unit (BRU), a two-stage process whereby cortical bone is remodeled from within.  The first stage of a BRU begins with osteoclastic erosion of bone in a “resorption canal” that advances lengthwise within the bone, forming a tunnel.  In the second stage, osteoblasts deposit bone, beginning at the origin of the resorption canal, which creates the “closing end” of the BRU. The continued centripal deposition of lamellae creates a new osteon.

As resorption advances, osteoblasts in the endosteum at the original site of resorption become active and begin to secrete osteoid onto the eroded surface.  The deposited osteoid eventually mineralizes, forming the outermost lamella of a newly forming osteon.  The process continues, lamella by lamella until an osteon is established.  This centripetal growth establishes the oldest lamella of an osteon at the periphery, with the youngest located immediately surrounding the Haversian canal.

As resorption advances, osteoblasts in the endosteum at the original site of resorption become active and begin to secrete osteoid onto the eroded surface.  The deposited osteoid eventually mineralizes, forming the outermost lamella of a newly forming osteon.  The process continues, lamella by lamella until an osteon is established.  This centripetal growth establishes the oldest lamella of an osteon at the periphery, with the youngest located immediately surrounding the Haversian canal.

As resorption advances, osteoblasts in the endosteum at the original site of resorption become active and begin to secrete osteoid onto the eroded surface.  The deposited osteoid eventually mineralizes, forming the outermost lamella of a newly forming osteon.  The process continues, lamella by lamella until an osteon is established.  This centripetal growth establishes the oldest lamella of an osteon at the periphery, with the youngest located immediately surrounding the Haversian canal.

As resorption advances, osteoblasts in the endosteum at the original site of resorption become active and begin to secrete osteoid onto the eroded surface.  The deposited osteoid eventually mineralizes, forming the outermost lamella of a newly forming osteon.  The process continues, lamella by lamella until an osteon is established.  This centripetal growth establishes the oldest lamella of an osteon at the periphery, with the youngest located immediately surrounding the Haversian canal.

As resorption advances, osteoblasts in the endosteum at the original site of resorption become active and begin to secrete osteoid onto the eroded surface.  The deposited osteoid eventually mineralizes, forming the outermost lamella of a newly forming osteon.  The process continues, lamella by lamella until an osteon is established.  This centripetal growth establishes the oldest lamella of an osteon at the periphery, with the youngest located immediately surrounding the Haversian canal.

As resorption advances, osteoblasts in the endosteum at the original site of resorption become active and begin to secrete osteoid onto the eroded surface.  The deposited osteoid eventually mineralizes, forming the outermost lamella of a newly forming osteon.  The process continues, lamella by lamella until an osteon is established.  This centripetal growth establishes the oldest lamella of an osteon at the periphery, with the youngest located immediately surrounding the Haversian canal.

As resorption advances, osteoblasts in the endosteum at the original site of resorption become active and begin to secrete osteoid onto the eroded surface.  The deposited osteoid eventually mineralizes, forming the outermost lamella of a newly forming osteon.  The process continues, lamella by lamella until an osteon is established.  This centripetal growth establishes the oldest lamella of an osteon at the periphery, with the youngest located immediately surrounding the Haversian canal.

The outer boundary of the newly formed osteon is marked by a cement line that appears as a basophilic ring around the osteon due to its higher concentration of ground substance.