Digital Histology
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Blood: Neutrophil

Four examples of neutrophils, a type of granular leucocytes, are shown in this image. Granular leucocytes are differentiated by the affinity of their specific granules for the dyes in the stain commonly used for blood smears.  Granules of neutrophils have little affinity for dyes. Neutrophils, also called polymorphonuclear leucocytes (PMN’s, “polys”) are the most abundant granulocyte and function as phagocytes in tissue. 1000x

Nucleus > <p>Neutrophils have a highly variable nucleus which is heterochromatic and consists of 3-5 lobes connected by thin chromatin strands. In females, a Barr body is visible (red arrows) which represents an inactivated, condensed X chromosome that is seen as a drumstick-shaped appendage on one of the lobes. The presence of a Barr body can be used to determine the sex of a person.</p>

Nucleus >

Neutrophils have a highly variable nucleus which is heterochromatic and consists of 3-5 lobes connected by thin chromatin strands. In females, a Barr body is visible (red arrows) which represents an inactivated, condensed X chromosome that is seen as a drumstick-shaped appendage on one of the lobes. The presence of a Barr body can be used to determine the sex of a person.
Granules > <p>Neutrophils readily move from the blood to sites of tissue inflammation, infection and trauma. They form the first line of defense in the body against invading microorganisms and, along with macrophages, are the major phagocytic cells in tissues. Their weakly-stained specific granules contain a number of enzymes that aid in their migration through tissue as well as in their phagocytic function. The less numerous azurophilic (blue-staining) granules are common to all granulocytes.</p>

Granules >

Neutrophils readily move from the blood to sites of tissue inflammation, infection and trauma. They form the first line of defense in the body against invading microorganisms and, along with macrophages, are the major phagocytic cells in tissues. Their weakly-stained specific granules contain a number of enzymes that aid in their migration through tissue as well as in their phagocytic function. The less numerous azurophilic (blue-staining) granules are common to all granulocytes.
Red blood cells <p>Neutrophils readily move from the blood to sites of tissue inflammation, infection and trauma. They form the first line of defense in the body against invading microorganisms and, along with macrophages, are the major phagocytic cells in tissues. Their weakly-stained specific granules contain a number of enzymes that aid in their migration through tissue as well as in their phagocytic function. The less numerous azurophilic (blue-staining) granules are common to all granulocytes.</p>

Red blood cells

Neutrophils readily move from the blood to sites of tissue inflammation, infection and trauma. They form the first line of defense in the body against invading microorganisms and, along with macrophages, are the major phagocytic cells in tissues. Their weakly-stained specific granules contain a number of enzymes that aid in their migration through tissue as well as in their phagocytic function. The less numerous azurophilic (blue-staining) granules are common to all granulocytes.
Platelets <p>Neutrophils readily move from the blood to sites of tissue inflammation, infection and trauma. They form the first line of defense in the body against invading microorganisms and, along with macrophages, are the major phagocytic cells in tissues. Their weakly-stained specific granules contain a number of enzymes that aid in their migration through tissue as well as in their phagocytic function. The less numerous azurophilic (blue-staining) granules are common to all granulocytes.</p>

Platelets

Neutrophils readily move from the blood to sites of tissue inflammation, infection and trauma. They form the first line of defense in the body against invading microorganisms and, along with macrophages, are the major phagocytic cells in tissues. Their weakly-stained specific granules contain a number of enzymes that aid in their migration through tissue as well as in their phagocytic function. The less numerous azurophilic (blue-staining) granules are common to all granulocytes.
Main SlideNucleus >Granules >Red blood cellsPlatelets