Stratum spinosum: Langerhans cell
Langerhans cells are migratory macrophages that are involved in skin immunosurveillance, antimicrobial immunity, and the induction phase of contact hypersensitivity. They have an irregular nucleus, a clear cytoplasm and numerous tendril-like dendritic processes. After phagocytosing antigens, Langerhans cells migrate out of the epidermis, eventually reaching lymph nodes to initiate an immune response. Langerhans cells are most commonly seen in the stratum spinosum. 15,000x
Langerhans cell
Langerhans cells are migratory macrophages that are involved in skin immunosurveillance, antimicrobial immunity, and the induction phase of contact hypersensitivity. They have an irregular nucleus, a clear cytoplasm and numerous tendril-like dendritic processes. After phagocytosing antigens, Langerhans cells migrate out of the epidermis, eventually reaching lymph nodes to initiate an immune response. Langerhans cells are most commonly seen in the stratum spinosum. 15,000x
- Dendritic processes
Langerhans cells are migratory macrophages that are involved in skin immunosurveillance, antimicrobial immunity, and the induction phase of contact hypersensitivity. They have an irregular nucleus, a clear cytoplasm and numerous tendril-like dendritic processes. After phagocytosing antigens, Langerhans cells migrate out of the epidermis, eventually reaching lymph nodes to initiate an immune response. Langerhans cells are most commonly seen in the stratum spinosum. 15,000x
- Nucleus >
The irregular, indented nucleus reflects the monocyte/macrophage lineage of Langerhans cells.
PREVIOUS