Secondary lymphoid nodule
This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x
Secondary nodule
This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x
- Germinal center
This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x
- - Dark zone
This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x
- - Light zone
This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x
- Mantle
This secondary nodule demonstrates the zonation visible within the germinal center. In the dark zone, B cells proliferate and undergo random mutations of their antibody-producing genes. These B cells are then selected in the light zone, based on their antibody’s ability to bind to an antigen. Those with high-affinity antibodies undergo further proliferation and form large, pale-staining immunoblasts. Prodigy of these cells become plasma cells and B memory cells. Cells with disadvantageous mutations are eliminated by apoptosis and phagocytosis by macrophages. Lymph node, 200x
Area shown in next image >
The area in the rectangle is shown at higher magnification in the next image.
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