Germinal center
After antigenic stimulation, large immunoblasts in the germinal center divide to form B lymphocytes that accumulate in the peripheral mantle. Mitotic figures indicate this activity. Reticular connective tissue and the reticular cells that produce them form the stroma of the nodule. Macrophages and antigen-presenting cells are also present in the germinal center. 1000x
Germinal center
After antigenic stimulation, large immunoblasts in the germinal center divide to form B lymphocytes that accumulate in the peripheral mantle. Mitotic figures indicate this activity. Reticular connective tissue and the reticular cells that produce them form the stroma of the nodule. Macrophages and antigen-presenting cells are also present in the germinal center. 1000x
- Immunoblasts
After antigenic stimulation, large immunoblasts in the germinal center divide to form B lymphocytes that accumulate in the peripheral mantle. Mitotic figures indicate this activity. Reticular connective tissue and the reticular cells that produce them form the stroma of the nodule. Macrophages and antigen-presenting cells are also present in the germinal center. 1000x
- Mitotic figures
After antigenic stimulation, large immunoblasts in the germinal center divide to form B lymphocytes that accumulate in the peripheral mantle. Mitotic figures indicate this activity. Reticular connective tissue and the reticular cells that produce them form the stroma of the nodule. Macrophages and antigen-presenting cells are also present in the germinal center. 1000x
- Macrophages >
Macrophages (tingible body macrophages), with phagosomes in their cytoplasm, indicate the phagocytic activity occurring in the germinal center. The term “tangible” refers to the fact that the phagocytosed material is stainable.
Mantle
After antigenic stimulation, large immunoblasts in the germinal center divide to form B lymphocytes that accumulate in the peripheral mantle. Mitotic figures indicate this activity. Reticular connective tissue and the reticular cells that produce them form the stroma of the nodule. Macrophages and antigen-presenting cells are also present in the germinal center. 1000x
- Small lymphocytes
After antigenic stimulation, large immunoblasts in the germinal center divide to form B lymphocytes that accumulate in the peripheral mantle. Mitotic figures indicate this activity. Reticular connective tissue and the reticular cells that produce them form the stroma of the nodule. Macrophages and antigen-presenting cells are also present in the germinal center. 1000x
Reticular cells >
The stroma of the nodule is reticular connective tissue, an open meshwork of delicate reticular fibers on which are suspended the various functional cells of the nodule. Reticular cells that produce this meshwork have nuclei that resemble those of active fibroblasts.
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