Germinal center
After antigenic stimulation, those B cells that have been selected for their high affinity antibodies, undergo further proliferation forming large immunoblasts in the lighter zone of the germinal center. Immunoblasts divide to form plasma cells and B memory cells. Mitotic figures indicate this activity. 1000x
Germinal center
After antigenic stimulation, those B cells that have been selected for their high affinity antibodies, undergo further proliferation forming large immunoblasts in the lighter zone of the germinal center. Immunoblasts divide to form plasma cells and B memory cells. Mitotic figures indicate this activity. 1000x
- Immunoblasts
After antigenic stimulation, those B cells that have been selected for their high affinity antibodies, undergo further proliferation forming large immunoblasts in the lighter zone of the germinal center. Immunoblasts divide to form plasma cells and B memory cells. Mitotic figures indicate this activity. 1000x
- Mitotic figures
After antigenic stimulation, those B cells that have been selected for their high affinity antibodies, undergo further proliferation forming large immunoblasts in the lighter zone of the germinal center. Immunoblasts divide to form plasma cells and B memory cells. Mitotic figures indicate this activity. 1000x
- Tingible body macrophages >
Non-selected B cells undergo apoptosis and are phagocytosed by macrophages, called tingible body macrophages. The term “tangible” refers to the fact that the phagocytosed material in their cytoplasm is stainable.
Mantle
After antigenic stimulation, those B cells that have been selected for their high affinity antibodies, undergo further proliferation forming large immunoblasts in the lighter zone of the germinal center. Immunoblasts divide to form plasma cells and B memory cells. Mitotic figures indicate this activity. 1000x
- Small lymphocytes
After antigenic stimulation, those B cells that have been selected for their high affinity antibodies, undergo further proliferation forming large immunoblasts in the lighter zone of the germinal center. Immunoblasts divide to form plasma cells and B memory cells. Mitotic figures indicate this activity. 1000x