Secondary lymphoid nodule

With antigenic stimulation, primary nodules increase in size and develop a pale-staining central region called the germinal center. These are now referred to as secondary nodules. Germinal centers are a morphological indication of lymphoid tissue response to antigen and represent a cascade of events including activation and proliferation of lymphocytes, and generation of plasma cells and memory B cells. Colon, 200x

Germinal centers develop from proliferating lymphocytes after antigen stimulation. These large, pale-staining cells are called immunoblasts, whose progeny differentiate into plasma cells and B memory cells.

The mantle zone surrounds the germinal center and consists mostly of B cells that have not been stimulated by antigen.

With antigenic stimulation, primary nodules increase in size and develop a pale-staining central region called the germinal center. These are now referred to as secondary nodules. Germinal centers are a morphological indication of lymphoid tissue response to antigen and represent a cascade of events including activation and proliferation of lymphocytes, and generation of plasma cells and memory B cells. Colon, 200x

With antigenic stimulation, primary nodules increase in size and develop a pale-staining central region called the germinal center. These are now referred to as secondary nodules. Germinal centers are a morphological indication of lymphoid tissue response to antigen and represent a cascade of events including activation and proliferation of lymphocytes, and generation of plasma cells and memory B cells. Colon, 200x

With antigenic stimulation, primary nodules increase in size and develop a pale-staining central region called the germinal center. These are now referred to as secondary nodules. Germinal centers are a morphological indication of lymphoid tissue response to antigen and represent a cascade of events including activation and proliferation of lymphocytes, and generation of plasma cells and memory B cells. Colon, 200x

With antigenic stimulation, primary nodules increase in size and develop a pale-staining central region called the germinal center. These are now referred to as secondary nodules. Germinal centers are a morphological indication of lymphoid tissue response to antigen and represent a cascade of events including activation and proliferation of lymphocytes, and generation of plasma cells and memory B cells. Colon, 200x

This image was taken of a slide in the University of Michigan slide collection.