Germinal center

In the germinal center, B cells proliferate, altering their antibody-producing genes to diversify the humoral immune response. The cells then undergo a selection process whereby only those with the highest affinity antibodies survive to form immunoblasts. The remaining cells are eliminated through apoptosis and subsequent phagocytosis by macrophages. These macrophages are termed tingible body macrophages because the phagocytosed remnants of the B cells in their cytoplasm are readily stainable. 1000x

In the germinal center, B cells proliferate, altering their antibody-producing genes to diversify the humoral immune response. The cells then undergo a selection process whereby only those with the highest affinity antibodies survive to form immunoblasts. The remaining cells are eliminated through apoptosis and subsequent phagocytosis by macrophages. These macrophages are termed tingible body macrophages because the phagocytosed remnants of the B cells in their cytoplasm are readily stainable. 1000x

In the germinal center, B cells proliferate, altering their antibody-producing genes to diversify the humoral immune response. The cells then undergo a selection process whereby only those with the highest affinity antibodies survive to form immunoblasts. The remaining cells are eliminated through apoptosis and subsequent phagocytosis by macrophages. These macrophages are termed tingible body macrophages because the phagocytosed remnants of the B cells in their cytoplasm are readily stainable. 1000x

In the germinal center, B cells proliferate, altering their antibody-producing genes to diversify the humoral immune response. The cells then undergo a selection process whereby only those with the highest affinity antibodies survive to form immunoblasts. The remaining cells are eliminated through apoptosis and subsequent phagocytosis by macrophages. These macrophages are termed tingible body macrophages because the phagocytosed remnants of the B cells in their cytoplasm are readily stainable. 1000x