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Overview: Aggregates of lymphoid nodules
Aggregates of lymphoid nodules are present in certain organs, including tonsils, distal regions of the small intestine (Peyer’s patches) and appendix. 50x, 10x, 20x

Tonsil >
Tonsils consists of aggregations of diffuse and nodular lymphoid tissues located in the lamina propria of the oral and pharyngeal mucosae. They are partially surrounded by a connective tissue capsule. The three types of tonsils (palatine, pharyngeal and lingual) form a ring, called “Waldeyer’s ring”, around the entrances of the nasal and oral cavities into the pharynx.

- Diffuse lymphoid tissue
Tonsils consists of aggregations of diffuse and nodular lymphoid tissues located in the lamina propria of the oral and pharyngeal mucosae. They are partially surrounded by a connective tissue capsule. The three types of tonsils (palatine, pharyngeal and lingual) form a ring, called “Waldeyer’s ring”, around the entrances of the nasal and oral cavities into the pharynx.

- Secondary nodules
Tonsils consists of aggregations of diffuse and nodular lymphoid tissues located in the lamina propria of the oral and pharyngeal mucosae. They are partially surrounded by a connective tissue capsule. The three types of tonsils (palatine, pharyngeal and lingual) form a ring, called “Waldeyer’s ring”, around the entrances of the nasal and oral cavities into the pharynx.

- Epithelium >
Tonsilar tissue is surfaced by the moist, stratified squamous epithelium of the oral and pharyngeal mucosae. Beneath the tonsil is connective tissue of the submucosa.

- Connective tissue
Tonsilar tissue is surfaced by the moist, stratified squamous epithelium of the oral and pharyngeal mucosae. Beneath the tonsil is a partial capsule consisting of submucosal connective tissue.

Peyer’s patch >
The lamina propria in the distal portions of the small intestine contains accumulations of MALT called Peyer’s patches, as seen in this section of the ileum.

Appendix >
The appendix, an appendage of the large intestine, is heavily infiltrated with MALT forming large numbers of lymphoid nodules.

- Diffuse lymphoid tissue
The appendix, an appendage of the large intestine, is heavily infiltrated with MALT forming large numbers of lymphoid nodules.

- Secondary nodules
The appendix, an appendage of the large intestine, is heavily infiltrated with MALT forming large numbers of lymphoid nodules.

Image source >
This image was taken of a slide in the Oklahoma State University slide collection.