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Mucosa: Epithelium
The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x
![Epithelium <p>The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x </p>](https://digitalhistology.org/wp-content/uploads/2024/05/Or.Dig_.Tub_.SmI_.Ov-6-1-yellow-ping.png)
Epithelium
The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x
![- Enterocytes <p>The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x</p>](https://digitalhistology.org/wp-content/uploads/2024/05/Or.Dig_.Tub_.SmI_.Ov-6-2-yellow-ping.png)
- Enterocytes
The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x
![- Microvilli <p>The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x </p>](https://digitalhistology.org/wp-content/uploads/2024/05/Or.Dig_.Tub_.SmI_.Ov-6-3-ping.png)
- Microvilli
The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x
![- Goblet cells <p>The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x </p>](https://digitalhistology.org/wp-content/uploads/2024/05/Or.Dig_.Tub_.SmI_.Ov-6-4-ping.png)
- Goblet cells
The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x
![Lymphocytes and macrophages <p>The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x </p>](https://digitalhistology.org/wp-content/uploads/2024/05/Or.Dig_.Tub_.SmI_.Ov-6-5-ping.png)
Lymphocytes and macrophages
The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x
![Lamina propria <p>The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x </p>](https://digitalhistology.org/wp-content/uploads/2024/05/Or.Dig_.Tub_.SmI_.Ov-6-6-ping.png)
Lamina propria
The small intestine is lined by a simple columnar epithelium, primarily composed of absorptive enterocytes with microvilli. Scattered goblet cells with their expanded apical portions containing mucinogen are visible. Also present are lymphocytes, macrophages and microfold or M cells. M cells (not visible here) occur among the enterocytes, but lack microvilli; instead having microfolds of their apical surface membrane that endocytose antigens, transporting them to surveilling lymphoid tissue in the lamina propria beneath them. M cells are antigen delivery cells for initiating mucosal immune responses. 1000x