Tunics

The mucosa (or mucous membrane) is the most interior of the tunics, lining the lumen.  The mucosa has three layers:  an innermost epithelium; a lamina propria of loose connective tissue; and a muscularis mucosae of smooth muscle, which is not always present.   Frequently, mucus-secreting glands are associated with this tunic, giving origin to its name.

An epithelium (either stratified squamous or simple columnar) forms the innermost layer of the digestive mucosa, the epithelial type varying with the organ and its function.  This epithelium also serves as a barrier to foreign agents entering the body.  The simple columnar epithelia may possess microvilli and/or unicellular glands or may be modified to form a sheet gland.

The lamina propria (yellow arrows) is a layer of loose connective tissue immediately beneath the epithelium.  Frequently, glands (blue arrow) will be present in this layer; these glands open onto the surface of the epithelium.  Diffuse and nodular lymphoid tissue (MALT, mucosa-associated lymphoid tissue) may be located in the lamina propria also.

The muscularis mucosae (literally, muscle of the mucosa) is composed of smooth muscle; this layer may be lacking or incomplete in some organs of the digestive tract.

The submucosa (black arrows) is composed of dense connective tissue.  Glands (blue arrows) may be present in the submucosa; these glands also open onto the epithelial surface.

The muscularis externa, the third tunic, is usually composed of smooth muscle.  Most frequently, this smooth muscle is arranged into an inner circular and an outer longitudinal layer.

The muscularis externa, the third tunic, is usually composed of smooth muscle.  Most frequently, this smooth muscle is arranged into an inner circular and an outer longitudinal layer.

The muscularis externa, the third tunic, is usually composed of smooth muscle.  Most frequently, this smooth muscle is arranged into an inner circular and an outer longitudinal layer.

The outermost tunic is either an adventitia or a serosa. The adventitia is a layer of connective tissue that becomes continuous with the connective tissue of the posterior body wall where organs contact that surface.

Where organs either face or protrude into the peritoneal cavity (diagrammed here), the adventitia is covered by a simple squamous epithelium (mesothelium, red arrows).  Together, the adventitia (black arrows) and the mesothelium constitute the serosa (serous membrane).

A mesentery is a double layer of serosa that suspends the tubular GI tract in the peritoneal cavity. For a complete review of serosa versus adventitia and mesentery, see “Organs & Systems, General Concepts, Membranes.”

Glands opening onto surface epithelium may be located in several positions within the tunics of the tubular digestive organs:  epithelium (red arrow); lamina propria (green arrow); or submucosa (blue arrows).  Also, glands (circled), such as liver or pancreas, may lie external to the tubular digestive system with a duct (black arrow) leading onto the epithelial surface of the tube.

Plicae circulares are folds of submucosa and overlying mucosa that extend around the circumference of the small intestine to increase surface area.