Liver: sinusoids

Sinusoids are discontinuous capillaries that separate plates of hepatocytes. Kupffer cells, spanning the lumen of these sinusoids, are a type of macrophage that phagocytose aging red blood cells and other debris in the sinusoidal lumen. Like other macrophages, their cytoplasm contains large numbers of lysosomes and often appears vacuolated and lacy. 1000x

Sinusoids are discontinuous capillaries that separate plates of hepatocytes. Kupffer cells, spanning the lumen of these sinusoids, are a type of macrophage that phagocytose aging red blood cells and other debris in the sinusoidal lumen. Like other macrophages, their cytoplasm contains large numbers of lysosomes and often appears vacuolated and lacy. 1000x

Kupffer cells belong to the mononuclear phagocyte series of phagocytic cells, which include macrophages, Langherhans cells in the skin, osteoclasts and alveolar macrophages.

Kupffer cells belong to the mononuclear phagocyte series of phagocytic cells, which include macrophages, Langherhans cells in the skin, osteoclasts and alveolar macrophages.